In a four-week clinical study, Dr. Edward Andujar and
Dr. Hitendra Shah evaluated a group of volunteer
subjects at the Wellness Medical Clinic in Diamond
Bar, California. The volunteer subjects showed an
improvement in several indicators of gut health following
four weeks of supplementation with two DIGESTIVE+++
capsules and two Laminine capsules taken daily.
The subjects were asked to refrain from using other supplements prior to the
study and provided the doctors with initial baseline stool samples. Data from the
Comprehensive Digestive Stool Analysis (Genova Diagnostics, Asheville, North
Carolina) showed a substantial improvement in total Short Chain Fatty Acids
(SCFAs) and butyrate production. The increase of these components is a defi nite
indicator that the gut is reestablishing a healthier microbiome. Good probiotics
are fermenting unabsorbed dietary fi ber, which supports many factors relating
to gut health.
BENEFITS OF SCFAs
Short Chain Fatty Acids (butyrate, acetate and propionate) are produced by the
anaerobic (absence of air) bacterial fermentation of primarily non-absorbed dietary
fi ber. They serve several important functions:
• Provide energy for cells lining the digestive tract.
• Act as an anti-diarrheal agent by removing sodium and water from the colon.
• Improve colonic blood fl ow.
• Deter the colonization of pathogens in the bowel.
• Provide 5-30 percent of systemic daily energy requirements.
• Reduce ammonia uptake from the intestine.
Low levels of total SCFAs or butyrate can be increased by:
• Dietary fi ber
• Larch arabinogalactans (a fi ber that ferments in the intestine).
• Normalization of pH-levels (In the GI tract, SCFA production is
higher when the colonic pH is between 5-8).
• Normalization of transit time. (Chronically slow transit time
can lead to bacterial overgrowth of the small intestine and high
SCFAs; very rapid transit time can also lead to high SCFAs).
• Consuming prebiotics and probiotics such as
fructooligosaccharides and Bacillus coagulans
(found in the DIGESTIVE+++ formula). Bacillus
coagulans is a Lactobacillus bacteria that
produces lactic acid. It acts as a substrate for other
gut bacteria that ferment it into SCFAs.
• Butyric acid (oral or rectal).
SOME DIETARY FIBERS MORE EFFECTIVE THAN OTHERS
In general, the more slowly fermented (insoluble) forms of fi ber
maintain low pH and raise SCFAs (especially butyrate) along the
entire length of the bowel. While both soluble and insoluble fi ber
foods are important for health, digestion and preventing diseases,
insoluble fi ber passes through our intestines largely intact and
becomes fuel for good bacteria in the colon. It also supports
Butyrate production, one of the best fuels to support gut health.
In conclusion, supplementing with Laminine and DIGESTIVE+++
products from LifePharm showed indication that short-chain fatty
acids (especially butyrate, the most benefi cial) are being increased
over a relatively short time. The formula created by LifePharm for a
probiotic, prebiotic and digestive enzyme product was formulated
with science-based trials evaluating each selected ingredient.
Taking DIGESTIVE+++ and Laminine as directed is a very positive
intervention to support optimal digestive tract and colon health.
BUTYRATE SUPPORTS REDUCED INFLAMMATION OF
During the four-week study, butyrate had a supporting role in
reducing infl ammation of the bowel. Butyrate acts as a good fuel
for the cells lining the colon and keeps them properly nourished.
This can protect against infl ammation and tears forming in the gut
lining. In certain imbalances of the colon and GI tract, butyrate
has been shown to decrease markers of infl ammation. People that
experience bowel irritation conditions (especially those that may
include mild diarrhea) tend to have lower total SCFAs.